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Air pollution linked to blood clots 5-13-08
Long-term exposure to a type of air pollution, the air-borne fine particles,
appears to dramatically increase the risk of deep vein thrombosis, a condition
that can lead to a life-threatening pulmonary embolism, according to a study in
the May 12 issue of the Archives of Internal Medicine.
Deep vein thrombosis (throm-BO-sis), or DVT, is a blood clot that forms in a
vein deep in the body. Most deep vein blood clots occur in the lower leg or
thigh although they can also occur in other parts of the body. This type of
clots is dangerous when they break loose and travel through the bloodstream to
the lungs, causing pulmonary embolism.
The study showed that people with DVT tended to have a higher exposure to air
pollution than controls. After considering other factors, researchers found an
increase in particulate matter of 10 micrograms per cubic meter increased the
risk of DVT by 70 percent. Blood from people exposed to more air pollution of
this sort needed less time to clot.
Air pollution with particulate matter smaller than 10 micrometers in diameter or
about one-40th the width of a human hair has been known to increase risk of a
number of diseases including asthma, chronic bronchitis, heart attack, stroke
and death in people with heart or lung disease.
Particulate air pollution can be caused by a range of fine particles often
coming from the exhaust of vehicles, particularly those with diesel engines and
burning of fossil fuels. It can be caused also by other pollutants such as road
dust, fly ask, wood smoke and sulfate aerosols.
National Resources Defense Council estimated that particulate air pollution
causes approximately 64,000 premature deaths from cardiopulmonary causes each
year, accounting for 6.5% of all cardiopulmonary deaths - 986,000 per year.
Dr. Andrea Baccarelli an assistant professor at the University of Milan and
colleagues conducted the study at the Harvard School of Public Health. They
compared 870 residents with DVT in the Lombardy region of Italy with 1,210
residents without this condition for their exposure to the air pollution of
particulate matter between 1995 and 2005.
The researchers found the association between fine particle exposure and blood
clots was stronger in men than in women, but non-existent among women taking
oral contraceptives or hormone therapy, which are known independent risk factors
for DVT as the current study confirmed.
"Given the magnitude of the observed effects and the widespread diffusion of
particulate pollutants, our findings introduce a novel and common risk factor
into the pathogenesis of deep vein thrombosis and, at the same time, give
further substance to the call for tighter standards and continued efforts aimed
at reducing the impact of urban air pollutants on human health," the researchers
conclude.
Air Pollution May Increase DVT Risk
Chronic exposure to air pollution alters the blood's coagulation properties
and heightens the risk of deep vein thrombosis (DVT), investigators here
concluded.
The risk of a clot increased by 70% with each 10 μg/m3 rise in particulate
matter, Andrea Baccarelli, M.D., Ph.D., of Harvard School of Public Health, and
colleagues, reported in the May 12 issue of Archives of Internal Medicine.
A near-linear relationship emerged from the range of particulate matter
concentrations.
"Given the magnitude of the observed effects and the widespread diffusion of
particulate pollutants, our findings introduce a novel and common risk factor
into the pathogenesis of DVT and, at the same time, give further substance to
the call for tighter standards and continued efforts aimed at reducing the
impact of urban air pollutants on human health," the authors concluded.
Exposure to air pollution has been linked to hypercoagulability and increased
risk of heart disease and stroke, the researchers said. Moreover, recent studies
have demonstrated a shortened prothrombin time in association with higher levels
of particulate air pollution of less than 10 μm in aerodynamic diameter (PM10).
Procoagulant abnormalities correlate more strongly with venous rather than
arterial thrombosis, they said.
In preclinical models, they noted, experimental exposure to air pollution
induced venous thrombosis. Whether air pollution has a similar effect on humans
had not been reported.
To examine that, Dr. Baccarelli and colleagues studied 870 patients with DVT
diagnoses from 1995 through 2005 in the Lombardy region of northern Italy.
Investigators estimated exposure to PM10 in the year before DVT diagnosis and in
1,210 individuals without DVT from the same area.
Comparison of the two groups showed that a higher mean PM10 was associated with
a shortened prothrombin time in cases and controls (P=0.04).
A 10 μg/m3 rise in PM10 was associated with an odds ratio of 1.70 for DVT (95%
CI 1.30 to 2.23, P<0.001).
The association was weaker in women than in men (OR 1.40, 95% CI 1.02 to 1.92,
P=0.02 versus OR 2.07, 95% CI 1.50 to 2.84, P<0.001). Use of oral contraceptives
or hormone therapy further lowered the risk in women (OR 0.97, 95% CI 0.58 to
1.61).
"We surmise that prothrombotic mechanisms are already activated in [women]
receiving hormone therapy so that they undergo less or no further induction
after air particle exposure," the authors said, alluding to the procoagulant
effects of oral contraceptives and hormone therapy.
Although increased exposure to air pollution shortened prothrombin time in cases
and controls, the authors said the thrombosis patients tended to have higher
PM10 levels compared with controls.
The study had several limitations including choice of controls from the same
locations as patients, raising the possibility that the controls were exposed to
more air pollution than the general population, and lack of data about the
amount of time spent outdoors by both groups. Air pollution exposure was
determined by ambient air pollution at the location.
The premise that air pollution increases DVT risk is plausible, "given the
underlying common soil behind arterial atherosclerosis and venous thrombosis,"
Robert D. Brook, M.D., of the University of Michigan, said in an editorial in
the same issue.
However, Dr. Brook questioned the magnitude of the reported association. The
difference is greater than that reported for arterial thrombosis and for other
factors that influence DVT risk, such as cigarette smoking.
Dr. Brook also said the lack of an additive effect of air pollution on
underlying mechanisms of thrombophilia was unexpected and should be explored
further in future studies.
Despite his questioning, Dr. Brook concluded that "some degree of clinically
meaningful association between ambient particulate air pollution and venous
thrombosis appears to be likely existent and worthy of future attention."
What you can do about Indoor Air Pollution to Reduce Asthma:
Reducing all dirty and foreign particles your children's air not only raises
IQ, but reduces asthma and allergies. The greatest gift you can give your
children as well as yourself is to quit smoking. If you choose not to, at least
never allow smoking in your house or car even when your children aren't present.
The over 3000 chemical particles found in cigarette smoke cling to everything
and can be stirred back up at anytime.
Use allergen barrier covers for all mattresses and pillows. They are not
plastic like they used to be and are not noticeable at all under sheets. If you
have to have carpets in your Child's room vacuum weekly and use Fabreeze
Allergen Reducer (Do Not use Regular Fabreeze use only the one marked Alleregen
Reducer, Do not use any Fabreeze if you have Multiple Chemical Sensitivity) or a dust mite spray on all fabric or furry things. Always run
an ionizing HEPA filter. The Holmes brand room size for under $25 works just
fine!
When it comes to carpet care there is a brand of vacuum that uses water to
run the air through so 100% of all airborne pollutants are captured. It's called
HYLA and is the best vacuum around. For more information on it
email me. In
your current vacuum make sure you use HEPA Filters if your vacuum has them. Or
buy the strongest filtration you can get. If you have a bin type vacuum, never
empty inside the home; all the dust you just vacuumed up will go everywhere.
If you have a furnace don't use those cheap Blue filters. Make sure your
filter has a
MERV
rating of 7+ or it is useless. A MERV 7 or higher filter will remove mold,
dander and many other dangerous pollutants.
Strive to use no chemical cleaners. These release harmful volatile organic
compounds into the air. Read the
Article Easy Substitutions for Healthier Living for hints on switching to
healthy cleaners.
If you own pets bathe them at least once a month.
Feed them correctly and they will produce very few allergens.
Following these simple tips will drastically reduce dust and millions of
other nasty particles; which will keep you and your children healthier and as
this new study show, smarter.
The Best Option Is:
The Hyla: Filters 100% of everything out of the air, also sanitizes air,
vacuums, cleans carpet, all allergy free! No more ridiculous hepa filters and
expense, clean healthy air and home. The only FDA approved means to remove
Formaldehyde from the home. Payment Plans, affordable for everyone. Call for
information, you cannot buy anywhere else! 918-640-2973
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