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Aspirin Therapy Patients: Time of Day Pill is Taken More Important Than Dosage 5-16-08
A low-dose aspirin taken at bedtime was associated with significant 24-hour
reductions in blood pressure in a study of adults with prehypertension,
researchers reported here.
In a 244-patient trial, with a median age of 43, systolic blood pressure
decreased by 5.6 mm Hg and diastolic by a mean of 3.7 mm Hg when the aspirin was
taken at bedtime, said Ramón C. Hermida, Ph.D., of the University of Vigo in
Spain, at the American Society of Hypertension meeting.
But there was no benefit when 100 mg of aspirin was taken in the morning, Dr.
Hermida added.
The investigators recruited 244 patients with prehypertension (systolic of 120
to 139 mm Hg or diastolic of 80 to 89 mm Hg). Patients were randomized to
lifestyle intervention (diet and exercise counseling), 100 mg of aspirin at
awakening on top of lifestyle intervention, or 100 mg at bedtime on top of
lifestyle intervention.
Of the participants, 138 were women. An ambulatory monitoring device was used to
sample blood pressure and heart rate every 20 minutes from 7 a.m. to 11 p.m. and
every 30 minutes during nighttime hours for 48 hours, before treatment and after
three months of treatment.
Compared with baseline values, patients who took aspirin at bedtime had a
significantly greater nighttime dip in systolic blood pressure (P <0.05).
Awake, asleep, and 24-hour mean systolic pressures were significantly lower in
the bedtime aspirin group than in the morning aspirin group or the lifestyle
modification arm (P <0.001), he said.
Systolic blood pressure increases with age, which also increases the risk of
stroke, but Dr. Hermida said it may be possible to slow that increase in
systolic blood pressure with a low dose aspirin daily.
But daily aspirin therapy is not recommended for treatment of hypertension nor
is it recommended in those as young as the population in this study, commented
Sandra J. Talor, M.D., of the Mayo Clinic in Rochester, Minn., who was a
discussant at a press conference where the study was discussed.
Dr. Talor, a member of the ASH board of directors, said that even though aspirin
is generally well tolerated, it is not without risk. "Aside from the potential
GI toxicity, we have no idea what the effect would be of long-term, daily
aspirin therapy," she said.
For that reason she said the findings needed to be interpreted cautiously and
should not direct clinical decisions.
Comment:
Want the benefits of Aspirin therapy but don't want synthetic drugs; white willow bark (Salix alba) is what aspirin is synthesized from? All though there have been no formal studies, anecdotal evidence shows taking white willow bark capsules about 400-800mg a day will provide an even better benefit due to it's having all other available co-factors. Don't let the milligrams scare you! It is just the measurement of weight not the potency. Herb's and Drugs are measured differently!