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Mushroom extract stops growth of breast cancer cells
4-16-08
Extracts from a mushroom used
for centuries in Eastern Asian medicine may help stop breast cancer growth,
according to a new study published in the British Journal of Cancer.
The laboratory study showed an extract from Phellinus linteus significantly
inhibited cell growth in breast cancer cell cultures and possibly by blocking an
enzyme called AKT.
In humans, AKT is involved in controlling signals that lead to cell growth. It
can block apoptosis and promote cell survival, a risk factor for many types of
cancer.
The mushroom Phellinus linteus also known as son gen in Chinese medicine, sang-hwang
in Korean and meshimakobu in Japanese has early been found to have anticancer
properties against skin, lung and prostate cancer cells.
One study also published in August 1, 2006 in the British Journal of Cancer
suggested the mushroom extract together with chemotherapy may be used to treat
prostate cancer.
The study was conducted by Dr Chang-Yan Chen and colleagues at the Boston
University School of Medicine.
In the current study, Dr Daniel Sliva of the Methodist Research Institute in
Indianapolis and colleagues found the mushroom extract reduced proliferation of
cancer cells, suppressed their aggressive behavior and blocked formation of new
tumor-feeding blood vessels.
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