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Taking N-Acetylcysteine benefits patients undergoing CT scan
Taking N-Acetylcysteine prior to a CT
scan or angiogram may help patients prevent the kidneys from being damaged by
the iodine-containing contrast agents, according to a new study published in the
Annals of Internal Medicine.
For the study, Aine Kelly, M.D., M.S. at the University of Michigan Health
System and colleagues meta-analyzed data from 41 randomized controlled studies
and found taking this inexpensive drug protected patients against
contrast-induced nephropathy or kidney damage caused by contrast agents.
The results showed, however, other drugs including Theophylline did not provide
any benefit while furosemide actually raised the risk for kidney damages.
Contrast agents are commonly used to enhance the CT scan or angiogram imaging
effects, but are harmful to the kidneys. According to the authors, one in every
four high risk patients undergoing a CT scan experienced mild to moderate damage
to the kidneys. In certain cases, it caused acute kidney failure.
Patients who have diabetes or hear failure are already vulnerable and are at
high risk from contrast agents. For these people, taking N-acetylcysteine may be
more than necessary, the study suggested.
N-acetylcysteine has been already widely used to clear mucus in cystic fibrosis
patients, and to treat overdoses of acetaminophen. Tablets of prescription
version of N-acetylcysteine are sold at a price of 25 cents for 400 mg and
readily available from most pharmacies.