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Bacterium 'to blame for Crohn's' 10-21-08

Researchers believe the lack of a specific bacterium in the gut may be a cause of Crohn's disease.

A shortage of naturally-occurring bacteria is thought to trigger the inflammatory gastrointestinal disorder by over-stimulating the immune system.

Now a French team has highlighted the bug, Faecalibacterium prausnitzii, which they show secretes biochemicals that reduce inflammation.

The study appears in Proceedings of the National Academy of Sciences.

The researchers, from the Institut National de la Recherche Agronomique, had already shown that patients with Crohn's disease have a marked deficiency in bacteria from the Clostridium leptum group.

Their latest work shows that F. prausnitzii - a major component of this group - accounts for a large part of the deficit.

Bowel surgery

The researchers found that Crohn's patients who underwent bowel surgery were more likely to experience a recurrence of the condition if they had low levels of F. prausnitzii.

And in experiments on cultured cells, they showed that liquid in which F. prausnitzii had been grown provided an anti-inflammatory effect.

The researchers said that if ongoing animal trials prove successful, human patients could benefit from a probiotic treatment with F. prausnitzii.

Dr Anton Emmanuel, medical director of the digestive disorders charity Core, called the study "exciting" and agreed it raised the possibility of a therapeutic "replacement" therapy.

"It would be interesting to see how this finding relates to the emerging body of evidence looking at genetic changes in some patients with Crohn's disease, with the known abnormal gene being one that codes for the body's ability to recognize foreign bacteria."

Dr John Bennett, chairman of Core, said there was growing evidence that micro-organisms combined with immunological weaknesses to either cause, or exacerbate Crohn's symptoms.

However, he said: "The gut contains a huge number and variety of organisms, and many of them have been investigated without any single one seeming to be entirely responsible."

Dr Bennett said scientists were testing the theory that harmful bacteria could be neutralized, or at least counter-acted, by preparations of beneficial "probiotic" micro-organisms, but as yet no definitive proof of their effect had been produced.

Professor Jonathan Rhodes, a consultant gastroenterologist from the Royal Liverpool Hospital, described the study as "interesting".

However, he said: "It is too early to tell whether this will lead directly to a new treatment as other probiotics have tended to produce good results in animal studies only to prove disappointing in clinical trial in Crohn's disease."

Comments:

Many patients suffering from Crohn's and Crohn's related disorders have found great relief, if not total remission; with a combination of Real Kefir (made from grains, not store-bought), Bella Mira Perfect Flora HSO'S and Enterically Coated, Molecularly distilled Fish Oil (Nature's Way Fisol).

Enterically Coated, Molecularly distilled Fish Oil (Nature's Way Fisol), works like no other and is especially beneficial to those with inflammatory bowel disease; because it does not open up until it reaches the small intestine.

Another very important test for anyone suffering with bowel inflammatory disorders is blood allergen antibody testing. You need to make sure you don't eat anything that will cause an immune inflammatory response.

There are so many "probiotics" available on the market today, and even medical experts can't properly choose between them. Let's break them down with the pro's and con's.

Yogurt/ Drinkable Yogurt, Activia, DanActive etc: Just about weekly a new yogurt appears in your grocer's refrigerator; What is the difference? Well, first you need to know about regular yogurt. Most brands these days have at least added acidophilus and bifidum bacterias, the two that have been known the longest. These two bacterias (like most probiotics) are extremely susceptible to acid and only about 1% of the total amount actually make it into the small intestine, where they are actually needed.

Activia and other designer yogurts have new designer bacterias developed specifically for that company. Which is why you don't find the same bacteria in them, unlike regular yogurt. Freezing yogurt kills all bacteria so there is really no such thing as frozen yogurt, it's ice cream. In the winter months there is always a possibility the yogurt may have frozen or partially frozen.

Doctor's routinely recommend yogurt during antibiotic therapy. This makes no medical sense and is completely useless. The antibiotics you are taking will kill any good bacteria. Start taking your probiotics as soon as your antibiotics are done and continue for 10 days. I have tested all of them and found that only DanActive really seems to do anything.

Pro's: Yogurt in all of it's forms tastes great, is high in protein and calcium, healthier snack for kids than ice cream or pudding, useful in weight loss and a meal substitute when you can't chew solids.

Con's: Very week to no probiotic activity. High is sugar, artificial colors, or full of artificial sweeteners. Not shelf stable or portable for long periods of time.

Store Bought Kefir vs Real Kefir:  The kefir sold in stores is not real kefir, made from kefir grains. It is just yogurt starter with more probiotic strains. It cannot be duplicated more than 7 times whereas real kefir grains will work for life.  Real kefir must be stored in glass bottles as plastic would burst. Real kefir when sealed will release air like soda when opened.

Pro's:  Real Kefir made from grains is about the best prebiotic and probiotic you can get. Real Kefir also contains beneficial yeasts, and beta glucans like those found in mushrooms. The financial value is unbeatable since it lasts for life and can be shared. Real Kefir can also make champagne, cheese, bread, other diary, you are only limited by your imagination. And kefir grains can hibernate if you need to take a brake for a vacation. You can also flavor and sweeten it any way you want.  Kefir will start colonizing within 3 days. Real kefir grains are the best probiotics. Store bought kefir is just yogurt and will not do anymore for you but costs 200% more.

Con's:  Daily milk feedings and jars all over your kitchen. Not too portable

Probiotics Supplements:

There are so many different kinds, brands, forms, benefits and even flavors but even a trained natural medicine expert would have problems matching the probiotic with the need. One thing to remember right off the bat is: Unless your pill is enteric coated (to bypass the stomach and dissolve in the intestinal tract) only about 1% will make it past the stomach acid. The 1% that does make it has very little chance of implanting and growing without prebiotic food like FOS. Basically if not enterically coated probiotic pills as well as liquid supplements are a complete waste of money. I should also mention some companies (like YL) have immunity blends that contain probiotics in the same capsule as oregano oil or some other very strong natural antibiotic. Do you really think the antibiotic wont kill the probiotics in the same capsule?

Nature's Way has enterically coated probiotics at very affordable prices.

Pro:   Readily available, portable, affordable, and no side effects

Con:  Just about useless and a complete waste of money. If you have a strong candida population it will kill most probiotics and not allow them to colonize.

HSO's Haemostatic Soil Organisms/ Primal Defense:

HSO's have been in the mainstream for about 10 years. Most consumers have either not taken notice because health food store employees knew nothing about them; or they didn't understand the need.  HSO's are much better than probiotics as they are the precious soil organisms that we lack since we played in the dirt as children (if we were allowed to at all).

Pro's: Bella Mira Perfect Flora HSO's Can:

 A comparison of Perfect Flora vs Other Isolated Probiotics

Bella Mira Perfect Flora HSO's contain 16 strains, Garden of Life contain only 11. Basically besides Real Kefir Grains, HSO's are the next best thing!

Cons: Other brands are very expensive.

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