|
Essential Oils |
Bella Mira Essential Oil Supplements
Essential Oil Information and Use
|
Gluten Free |
Gluten Free Living and Recipes
|
Important Information |
Save Your Computer Free Protection
|
Great Products |
|
FREE Wellness Tests |
Hormone Balance Test New Improved
.gif)
|
Contact Us |
Our Shopping Cart Is:
ENDO: Diabetes Drug Puts Puberty in Its Place 6-16-08
SAN FRANCISCO, June 16 -- For girls showing signs of early puberty, metformin may delay onset of menstruation and allow more time for growth, researchers said here.
Low-dose metformin treatment over four years was associated with later menarche, half as much fat mass gain, and less insulin resistance among low birth weight girls who developed pubic hair before age eight, Lourdes Ibanez, M.D., Ph.D., of the University of Barcelona in Spain, reported at the Endocrine Society meeting.
These findings from a small, randomized clinical trial suggested that "adult height may be increased" since a faster puberty with earlier menses may ultimately stunt growth, Dr. Ibanez said. Girls gain height most rapidly in the years right before menarche.
There may also be other benefits to delaying puberty to the normal age, she noted.
Earlier studies have linked menstruation before age 12 to an increased risk of breast cancer and early breast development to polycystic ovary syndrome, a common cause of infertility.
Girls who develop "precocious pubarche" with pubic hair appearing before age eight also "are at high risk for developing an adipose state of hyperinsulinemic androgen excess that leads towards early menarche," she said.
To see the effect of insulin sensitization in this setting, Dr. Ibanez and colleagues studied 38 prepubertal, low birth weight girls with precocious pubarche within a larger controlled trial.
The girls were randomized to no treatment or metformin at a dose of 425 mg/d for two years, then 850 mg/d for another two years.
The average birth weight was 2.4 kg (5.3 lb). At baseline, their average age was 7.9 with a mean body mass index (BMI) of 18.4 kg/m2.
After four years, girls treated with metformin were less likely to have had their first menstrual cycle than untreated girls. They also had lower levels of insulin-like growth factor 1 and better lipid profiles.
Likewise, metformin was associated with lower rates of insulin resistance and hyperandrogenism at four years.
Metformin-treated participants gained 5.5 kg less fat than those in the control group for a 50% reduction, which was driven by less abdominal fat gain as measured by MRI abdominal fat partitioning scans.
Girls in the metformin group had half as much visceral fat and 50% lower ratios of both visceral-to-subcutaneous fat and leptin-to-high-molecular- weight adiponectin compared with those who were untreated.
Importantly, the researchers said, metformin did not impair vertical growth or bone development. Other measures of growth were similar between groups, including lean mass and bone mineral density.
Larger studies may be needed to confirm the results, particularly because metformin is not approved for treatment of type 2 diabetes in children younger than 10.
Comment:
This does not surprise me! As early on start of puberty is almost always due to excess hormones in the diet (usually estrogens). This or in addition to this combined with a typical American Diet causes early insulin resistance. This does not have to stay this way. There is alot of medical proof as well as social proof that later onset menstruation is healthier.
Girls who reach puberty early (6-11 years)
* have a greater chance of endometriosis, fibroid tumors and other "female problems"
* have larger, fibrous breasts than average
* tend to become sexually active earlier
* tend to marry, have children younger
* tend to be overweight (not helped by fat cells doubling at 16)
* miss more school
* have more social problems
* higher incidence of teenage depression
* higher chance of cancer later in life
*more likely to engage in drugs and alcohol
The first one alone should have been reason enough to drastically change lifestyles now! Here are the things you need to change to stop the progression of puberty. And it will make Mommy feel alot better too. And maybe Daddy will stop having mood swings.
Reduce extra hormones in the diet. Make sure all meat, milk, butter, ice cream, yogurt and other animal products are hormone free (preferably certified organic). Use only glass or ceramic to store your foods. No more Tupperware, Gladware etc... They release xenoestrogens. Don't use cling wrap either. Especially don't microwave in plastic. (You shouldn't be microwaving anyway.) Reduce all plastic use. Get a stainless steel water bottle! Quart and jelly canning jars are great for food storage. Also the glass bowls with plastic lids are ok , just don't let the food touch the plastic. Don't eat any Soy! Soy isn't good for anybody. Fermented soy is ok in moderation once the situation is under control.
Stop using chemical body products, shampoo, deodorant, conditioner, perfume etc.. These have hormone disrupters. Use natural and organic versions. The Easy Solutions For Healthier Living page makes all this easy!