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New clue to Alzheimer's disease found 6-23-08
A plague of beta-amyloid in the brain is believed to be the cause of
Alzheimer's disease. But new research suggests that not all forms of beta-amyloid
play a role in the disease, The Associated Press reports.
Researchers found from a study of rats that only a two-molecule form of beta-amyloid
causes the characteristics of Alzheimer's, but not other forms.
Dr. Ganesh M. Shankar and Dr. Dennis J. Selkoe of Harvard Medical School
manipulated extracts from the brains of people who died from Alzheimer's disease
and injected different forms of beta-amyloid in the brains of rats to see what
happens.
They found the insoluble plaque or the soluble one-molecule or three molecule
forms did not cause any detectable effect on the rats who received the
injections.
Only the rats that received two-molecule form of soluble beta-amyloid exhibited
signs of Alzheimer's such as impaired memory function, particularly newly
learned behaviors, the researchers reported in Sunday's online edition of the
journal Nature Medicine.
A study of mice also showed that the density brain cells were reduced by 47
percent, the AP reports. The beta-amyloid seemed to have an impact on synapses.
Now the researchers want to know why one form of beta-amyloid is harmful while
others are not.
Alzheimer's disease, a major form of dementia, affects an estimated 4.5 million
Americans. The disease is believed to begin after age 60. About 5 percent of men
and women age 65 to 74 have the disease while of those age 85 or older, half
have the disease.
There is no cure for the fatal Alzheimer's disease.
Comment:
Prevention is the cure to this disease. Stay away from all heavy metals.