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Resveratrol may prevent breast cancer 7-8-08
Taking the amount of resveratrol found in a glass of red wine could suppress
a carcinogenesis that would otherwise lead to breast cancer, according to a
laboratory study in the July 2008 issue of Cancer Prevention Research, a journal
of the American Association for Cancer Research.
Resveratrol is a naturally occurring phytochemical found in red wine, red grapes
and some nuts. It has been known to provide a range of health benefits such as
prevention of heart disease and cancer.
"Resveratrol has the ability to prevent the first step that occurs when estrogen
starts the process that leads to cancer by blocking the formation of the
estrogen DNA adducts," said Eleanor G. Rogan, Ph.D., lead author of the study.
"We believe that this could stop the whole progression that leads to breast
cancer down the road."
Rogan is a professor at the University of Nebraska Medical Center.
For the current study, Rogan and colleagues measured the effect of resveratrol
on cellular functions known to affect breast cancer.
They found resveratrol was powerful in terms of its suppression of formation of
some estrogen-DNA adducts, which would potentially lead to development of breast
cancer.
The results show as little as 10 umol/L, the amount that could be found in a
glass of red wine, which contains between 9 and 28 umol/L of resveratrol, would
suppress the DNA adducts.
Estrogen is known to fuel growth of breast cancer by reacting with DNA molecules
to form adducts, according to the authors.
What resveratrol suppressed was the expression of CYP1B1 and the formation of
2,3,7,8-Tetrachlorodibenzo-p-dioxin, two known risk factors for breast cancer,
the researchers found.
Rogan was cited in a news release as saying resveratrol works by inducing an
enzyme called quinone reductase, which reduces the estrogen metabolite back to
inactive form.
The real preventive effort in humans needs to be tested in trials, Rogan said.
Comment:
Resveratrol is available in supplements everywhere, but should you take them? No. Nutrients are absorbed best when taken with all their cofactors, (i.e. in it's natural state) and un-separated or processed to fit some made up standard. If wine is your preferred drink; make sure it is red, organic and un-sulfured for the most benefits. If you don't like wine you can get just as much form 100% juice Organic concord grapes!