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Red wine compound may help middle-aged men’s heart 7-7-08
A new study suggests that middle-aged men and women could slow aging-related
deterioration and functional decline by using resveratrol, a compound found in
red wine, grapes and nuts.
Resveratrol has been found in previous studies to have effects in animals
similar to what's induced by calorie restriction, which is known to extend
lifespan in many animal models.
The current study sponsored and conducted by the National institute on Aging
confirmed resveratrol has some effects of calorie restriction, but indicated
that this compound does not increase lifespan in study mice when fed a standard
diet.
The study led by Rafael de Cabo, Ph.D., of the Laboratory of Experimental
Gerontology at the NIA and colleagues compared mice fed a standard diet, a
high-calorie diet or an every-other-day feeding regimen with or without high- or
low-dose resveratrol for the aging related health conditions.
Calorie restriction including every-other-day feeding regimen has been showed to
improve markers of health, according to the study.
"Research is attempting to understand the process of aging and to determine how
interventions can influence this process. Dietary restriction has
well-documented health benefits in mammals, and the study of possible mimetics
of it, such as resveratrol, are of great interest," said NIA Director Richard J.
Hodes, M.D.
"Resveratrol has produced significant effects in animal models, now including
mice, where it mimics some, but not all, consequences of caloric restriction.
Its effects in humans remain to be studied."
The researchers found resveratrol prevented aging-related and obesity-related
cardiovascular functional decline in the mice as determined by several
parameters.
Resveratrol also significantly reduced total cholesterol in 22-month-old
non-obese mice after 10 months of treatment.
Additionally the aortas of 18-month-old obese and non-obese mice receiving
resveratrol functioned significantly compared to untreated mice. Plus, the
compound improved inflammation in the heart.
In addition to cardiovascular function, the researchers found resveratrol to
have a variety of positive impact on other aging-related problems in mice, cited
from a news release from NIH/National Institute on Aging
* Treated mice tended to have better bone health, as measured by thickness,
volume, mineral content and density, and bending stiffness compared to the
non-treated control group.
* At 30 months of age, resveratrol-treated mice were found to have reduced
cataract formation, a condition found to increase with age in control-group
mice.
* Resveratrol enhanced balance and motor coordination in aged animals.
Scientists found significant improvement in performance at 21 and 24 months
versus 15 months in the resveratrol-treated mice but not in the untreated mice.
* Resveratrol partially mimicked the effects of dietary restriction on the gene
expression profiles of liver, skeletal muscle and adipose (fatty) tissue in
mice.
In spite of all the benefits, resveratrol did not significantly increase
lifespan in animals fed standard chow, suggesting that the intervention did not
affect all aspects of the basic aging process.
The study showed mice on the high-calorie diet without resveratrol lived the
shortest length of time and those on an every-other-day regimen lived the
longest, regardless of resveratrol treatment.
In mice fed the high-calorie diet, however, mean and maximum lifespan increased
for those treated with resveratrol when compared with the mice on the high
calorie diet without resveratrol.
Regardless of the weight status, mice fed on the high calorie diet, but treated
with resveratrol lived longer or healthier than mice on the same diet but
without resveratrol.
The researchers explained that improved cardiovascular health and reduced fatty
changes in the liver may have contributed to the increased lifespan of
resveratrol-treated mice.
The results were based on an animal study; more research is needed to understand
how resveratrol affect human’s cardiovascular health and lifespan.
"We are learning a great deal about how resveratrol affects the health and
survival of mammals," said David A. Sinclair, Ph.D., of the Glenn Laboratories
for Molecular Biology of Aging at Harvard Medical School. "Continued study of
calorie restriction mimetics such as resveratrol may eventually point the way to
new medicines to treat diseases of aging."
Comment:
Resveratrol is available in supplements everywhere, but should you take them? No. Nutrients are absorbed best when taken with all their cofactors, (i.e. in it's natural state) and un-separated or processed to fit some made up standard. If wine is your preferred drink; make sure it is red, organic and un-sulfured for the most benefits. If you don't like wine you can get just as much form 100% juice Organic concord grapes!