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Rheumatoid arthritis is a risk factor for cardiovascular
disease 6-15-08
Rheumatoid arthritis patients have double the risk of cardiovascular events --
comparable to that of diabetes patients
Paris, France, Friday 13 June 2008: The risk of cardiovascular disease (CVD) for
people with rheumatoid arthritis (RA) has been found to be comparable to the
risk of CVD in people with type 2 diabetes, according to the conclusions of two
studies presented today at EULAR 2008, the Annual Congress of the European
League Against Rheumatism in Paris, France.
At least one CV-event was reported in 8.6% of the RA population studied, a
figure that was double that reported in the general population (4.3%),
corresponding with an incidence of 3.14 per 100 patient/years (95% confidence
interval (CI): 1.98-4.30) for RA patients, and 1.51 per 100 person/years
(95%-CI: 1.18-1.84) for the general population.
In a second study, the age- and gender- adjusted prevalence odds ratios for CVD
were found to be 2.3 (95%-CI: 1.3-4.0) for those with type 2 diabetes and 2.0
(95%-CI: 1.1-3.4) for those with RA, indicating a similar CVD risk for the two
diseases.
Dr Mike Peters of the VU University Medical Center and Jan van Breemen
Institute, Amsterdam, the Netherlands, an investigator in both studies (lead
investigator: Dr Michael T Nurmohamed), said, "These two studies suggest that RA
should be considered an important cardiovascular disease risk factor. Healthcare
professionals treating those with the disease should therefore be aware of this
elevated risk and advise their patients to follow a healthy diet and lifestyle
and be alert to the early signs and symptoms of CVD in addition to managing
their RA."
The studies both examined 353 randomly selected outpatients with RA (from the
CARRÉ study) and participants of a population-based cohort study on diabetes and
CVD (the Hoorn study). The first study compared 3-year incident CVD in both the
CARRÉ and Hoorn studies, using Cox proportional hazards models. In the second,
patients with normal fasting glucose levels from the CARRÉ study (n=294) were
compared to individuals from the Hoorn study with a normal glucose metabolism
(n=258) and individuals with type 2 diabetes (n=194). Both made adjustments for
other CV risk factors, i.e. blood pressure, anti-hypertensive agent use, total
cholesterol, statin use, waist to hip ratio and smoking.
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