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Stem cell therapy may have new challenge 6-9-08

A study by Mario Capecchi and colleagues from the University of Utah Health Sciences found a single organ may contain more than one type of adult stem cell, a discovery that complicates prospects for the stem cell therapy.

The researchers for the study published in the June 8 issue of the journal Nature Genetics a gene named Bmi1 to mark the presence of adult stem cells in the intestines of mice was mostly present in the upper third of the intestine.

The finding suggests that at least one or two other types of adult stem cells must exist to keep the middle and lower thirds of the mouse' guts functional.

The new discovery "is important because people are talking about stem cell therapy; they want to stick in stem cells to treat disease," says Capecchi, a winner of the 2007 Nobel Prize in Physiology or Medicine.

"People always thought about a uniform stem cell population in each organ, but now we are saying there are multiple stem cell populations in a given organ, so if you're going to do therapy, you have to recognize this complexity," adds Capecchi, co-chair and distinguished professor of human genetics at the University of Utah and an investigator with the Howard Hughes Medical Institute.