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Vitamin C inhibits replication of HIV
11-16-08
S. Harakeh and R. J. Jariwalla at Linus Pauling Institute of Science and
Medicine in Palo Alto, CA has done quite some research on the inhibitory effect
of vitamin C on HIV replication and found that this vitamin along with other
reducing agents may be used as a treatment to reduce the virus titer.
In a report published in the Dec 1991 issue of American Journal of Clinical
Nutrition, Harakeh and Jariwalla said they tested calcium ascorbate, a salt of
vitamin C, and two thiol-based reducing agents (glutathione and N-acetyl-L-cysteine
(NAC)) for their effect against the human immunodeficiency virus HIV-1
replication in chronically infected T lymphocytes.
They found that calcium ascorbate has the same magnitude of effect at reducing
extracellular HIV reverse transcriptase as ascorbic acid or vitamin C does. But
chronic exposure to ascorbate was necessary for HIV suppression. NAC, but not
glutathione caused less than twofold inhibition of HIV reverse transcriptase and
rendered a synergistic effect (about 8-fold inhibition) when tested together
with vitamin C.
Later in 1994, the researchers published another study in the June 1994 issue of
Chem Biol Interact saying that "the activity of an HIV LTR-directed reporter
protein made in ascorbate-treated cells was reduced to approximately 11%
relative to that of untreated control," indicating that vitamin C "exerts a
posttranslational inhibitory effect on HIV by causing impairment of enzymatic
activity."
In 1995, Harakeh and Jariwalla reported in the Sep-Oct issue of Nutrition that
"exposure to 300 micrograms/ml ascorbate (vitamin C in the form of salt)
resulted in approximately 5- to 10-fold lowering of the extra-cellular RT
(reverse transcriptase) titer. In contrast, no significant suppression in
extracellular RT levels was seen with concentrations of AZT (an antiviral drug)
in the range of 1-5 micrograms/ml."
Comments:
To find your daily maximum dose of Vitamin C is very easy. Start taking 1000
mg every hour When you achieve loose bowels or diarrhea then cut back 1000 mg
and that is your daily maximum dose. You may be able to tolerate more or less
depending on symptoms. It is nearly impossible to overdose on vitamin c, but
seek medical advice if taking over 10,000mg daily.
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