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Common OTC Pain Relievers Increase Muscle Mass in Weight Training 4-7-08
The findings of a recently conducted study seem to indicate that taking some
common over-the-counter (OTC) pain relievers may improve muscle mass when taken
during a weight-training program. The study was conducted with the elderly in
mind but the beneficial effect of the OTC medications may prove beneficial to
astronauts, too. They experience decreased muscle mass during extended periods
of weightlessness when in orbit.
The study involved a group of 36 men and women, aged 60 to 78, who enlisted in a
three-month weight-training program that required 15 to 20 minutes of exercise
three times a week. The study participants were divided into three groups, with
one group taking the manufacturer’s recommended dosage of ibuprofen, commonly
marketed as Advil; a second group taking the manufacturer’s recommended dosage
of acetaminophen, commonly marketed as Tylenol; and a third group taking a
placebo. The study was random so neither participants nor researchers knew who
was taking which medication until the end of the study.
The study, including the weight training sessions, took place at the Human
Performance Laboratory at Ball State University. The study was led by Dr. Todd
Trappe, who used magnetic resonance imaging (MRI), considered the gold standard
for measuring muscle mass of the quadriceps.
Participants in the placebo group developed more muscle mass during the study
period and their level of strength improved, too. This was the expected outcome.
But the participants taking the OTC medications showed significant increases in
both muscle mass and strength, surpassing the gains in the placebo group.
Biopsies of the muscles of the study participants are now being analyzed to
determine the exact metabolic mechanism that allowed the ibuprofen and
acetaminophen to boost muscle mass so remarkably.
Dr. Chad Carroll, a member of the Trappe research team, presented the findings
of the study at the April 6 meeting of Experimental Biology 2008 in San Diego.
The National Institutes of Health and an award from APS helped fund the study.
Source: Federation of American Societies for Experimental Biology