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Tart cherries may prevent heart disease and diabetes 4-7-08
Eating lots of tart cherries daily may help protect against heart disease and
diabetes, according to a study presented Sunday at the Experimental Biology 2008
meeting in San Diego, CA.
The animal study showed rats fed tart cherry powder had low levels of
inflammation, body fat, weight gain and blood cholesterol.
For the study, researchers from the University of Michigan Cardiovascular Center
fed rats whole tart cherry powder mixed into a high fat diet.
They found the rats on the cherry diet did not gain as much weight as rats that
did not receive cherries.
They also found that cherry-diet rats had low levels of inflammation that has
been linked to heart disease and diabetes, and low levels of cholesterol and
triglycerides than the other rats.
The results were observed in both lean and obese rats.
The obese rats used in the study were bred to have a predisposition to obesity
and insulin resistance. The researchers found these rats when fed cherry powder
were less likely to buildup fat in their bellies, another factor linked to
cardiovascular disease.
The lean rats were prone to high blood pressure, high cholesterol and impaired
glucose tolerance. In the study, they received a low-fat diet with or without
cherries.
Cherry-fed lean rats had lower total cholesterol, lower blood sugar, less fat
storage in the liver and lower oxidative stress.
But it is unknown whether these benefits would also be observed in the obese
rats or in rats fed a higher fat, western-style diet containing elevated
saturated fat and cholesterol.
The amount of cherries used in the rats' diet is equivalent to about 1.5 cups
every day for humans.
The researchers are preparing to do a pilot-phase clinical trial later this
spring to determine whether tart cherries will have the same effect in humans.
"These new findings are very encouraging, especially in light of what is
becoming known about the interplay between inflammation, blood lipids, obesity
and body composition in cardiovascular disease and diabetes," said Steven
Bolling, M.D., a U-M cardiac surgeon and the laboratory's director.
"The fact that these factors decreased despite the rats’ predisposition to
obesity, and despite their high-fat ‘American-style’ diet, is especially
interesting."
The study was funded by the Cherry Marketing Institute, a trade association for
the cherry industry, which has no influence on the design, conduct or analysis
of the research.