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Lab study demonstrates anti-cancer properties of vitamin D2 4-7-08
A study by researchers in Taiwan and published online on April 3 in Journal
of Agricultural and Food Chemistry found ergocalciferol or vitamin D2 was able
to inhibit leukemia cell growth in a dose-dependent manner.
For the study, Wei-Jen Chen and colleagues from Chung Shan Medical University
and other academic institutions in Taiwan tested vitamin D2 in HL-60 cells and
found the vitamin induced DNA fragmentation and increased sub-G1 DNA contents,
suggesting it may promote apoptosis.
Cancer cells keep growing because a cellular function known as apoptosis or
programmed cell death is missing in cancerous cells. Increased apoptosis could
inhibit cancer cell growth.
Chen and colleagues found vitamin D2 caused apoptosis probably through a
reactive oxygen species (ROS) dependent pathway.
They further found the vitamin also led to an increase in pro-apoptotic factor
Bax and decreased anti-apoptotic member Mcl-1. A Fas-mediated pathway may also
be involved in the vitamin D induced apoptosis.
The researcher concluded "these findings suggest that ergocalciferol (vitamin D)
causes HL-60 apoptosis via a modulation of mitochondria involving ROS
production, GSH depletion, caspase activation, and Fas induction. On the basis
of anticancer activity of ergocalciferol, it may be feasible to develop chemo
preventive agents from edible mushrooms or hop."
Comment:
Synthetic Vitamin D-2 (ergocalciferol) does not break down well in the body and can build up causing liver congestion. The best way to get real vitamin D is sunshine. 1/2 hour of sunshine gives you around 200mg of vitamin D. Any exposure will do. I put my arm up on the window sill while I'm driving. Do not wear sunblock during this time it can hamper D conversion.