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Low blood vitamin D means high risk of recurrence of breast cancer or death 5-16-08
A new study by researchers from the Johns Hopkins Kimmel Cancer Center and
other organizations suggests that taking vitamin D supplements may help breast
cancer patients.
The study led by Dr. Nancy Davidson, director of the breast cancer program and
colleagues showed women with breast cancer who had a vitamin D deficiency at the
time diagnosis had a higher risk of recurrence or death from the disease.
Davidson and team found only 24 percent of the patients had adequate levels of
vitamin D in their blood when the disease was diagnosed, which the researchers
said suggests that vitamin D deficiency is linked to poorer outcomes in breast
cancer patients.
But the results did not indicate how effective taking vitamin D supplements
would be at preventing death from breast cancer or the disease from recurring
although the authors suggested it would be beneficial to restore the vitamin D
level to the normal range.
For the study, the researchers measured vitamin D levels in 512 women at an
average age of 50, who were newly diagnosed with localized breast cancer between
1989 and 1995. They followed the patients for about 12 years.
They found 37.5 percent of the patients were deficient in vitamin D, 38.5
percent had inadequate levels of vitamin D while only 24 percent had levels in
the normal range.
Low vitamin D levels were more likely found in those who were pre-menopausal,
had more weight, high insulin levels and had more aggressive tumors, the study
showed. Older women were more likely to take more supplements.
Those who had deficient levels of vitamin D were twice as likely to have breast
cancer spreading as those who had the healthy levels. The risk of dying from the
disease was 75 percent higher in women with the lowest levels than those with
the optimal levels.
The current study is just one of many studies that suggest that vitamin D had
not only a preventative effect, but also therapeutic effect against breast
cancer in addition to other types of cancers.
The evidence is so strong that the Canadian Cancer Society has officially
recommended using 1,000 IU of this vitamin per day to prevent a variety of
cancer including breast cancer.
Another study released a few days earlier in the May-June 2008 issue of the
Breast Journal by Cedric F. Garland, Dr. P.H. and colleagues from the University
of California, San Diego linked to deficiency in exposure to sunlight and higher
risk of breast cancer.
Sunlight, especially ultraviolet B (UVB) exposure triggers photosynthesis of
vitamin D in the body, which is the main venue for humans to get vitamin D
although a limited number of foods also provide this vitamin. Deficiency of
sunlight exposure is likely to mean deficiency of vitamin D.
The researchers analyzed data from a database called GLOBOCAN, developed by the
World Health Organization's International Agency fro Research on Cancer, which
lists information on cancer incidence, mortality and prevalence for 175
countries.
The latitudes of 175 countries were associated with breast cancer incidence, the
analysis showed. Those countries at the highest latitude in both hemispheres had
highest incidence. The association held true even after other possible factors
such as meat, vegetable and alcohol intake were considered.